Abstract

FORMULATION AND EVALUATION OF FLOATING TABLET CONTAINING ANTI ULCERS AND ANTACID USING COMBINATION OF POLYMER

*Ramchandra Nirmal, Dr. Nidhi Bais and Dr. Sachin Kumar Jain

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Abstract

AIM: The aim of this research was to arrange a floating drug delivery system of Ranitidine hydrochloride (RHCL) so as to extend the gastric continuance and comparison of combination of polymer for excellent sustained effect. The tablets were prepared by direct compression. The drug: Polymer interactions make up my mind by IR spectroscopic method. The pre and post compression studies were performed by using IP standard formula and procedure. Drug release from the floating drug delivery system was studied using IPІ. The release behavior of combination of polymer was compared per obtained data. The discharge data were subjected to different models zero order, first order Higuchi and Pappas so as to gauge their release kinetics and mechanisms. The hardness of all formulations was found to be within the range of 5.3±0.15 to 8.6±0.05 kg/cm². Among these all formulations (F1 to F8) prepared by direct compression, batch F6 was best formulation and showed very slow release i.e. 74.3% in 6 h. The drug release of the opposite formulation like F1, F2, F3, F4, F5, F7, F8 (94.2 %, 91.8 %, 88.51% 90.5 % 89.5 % 74.3% 86.12% 88.65% in 5.5h) was higher from the F1 formulation prepared by direct compression. The drug release was observed by fickian diffusion mechanism. the discharge kinetics of the formulation F1and F2, F3, F4, F5, F8 shows more release as compare to F6 and F7. Combination of polymer shows better sustained release properties. The formulation with Carbopol 934 and Tara gum HPMC different grade shows better sustained release effect. The developed floating tablets of RHCL could even be utilized in clinic for prolonged drug release for a minimum of 6hrs, thereby improving the bioavailability.

Keywords: HCL, gastro retentive, floating drug delivery, sustained release.