Abstract

PREPARTION AND EVALUATION OF HERBAL GEL USED IN THE TREATMENT OF ATOPIC DERMATITIS (ECZEMA)

Vishakha K. Patthe* and Manish P. Surung

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Abstract

This study aimed to create a gel using Turmeric and Tagetes erecta leaves extracts for treating Atopic dermatitis (eczema). Extraction involved maceration using acetone for Turmeric and methanol for Tagetes erecta leaves. Physicochemical assessments, including total ash values, revealed 4.92% and 5.61% for Turmeric and Tagetes erecta extracts, respectively. Phytochemical analysis detected secondary metabolites in both extracts. Chromatographic separation (TLC and HPTLC) identified curcumin in turmeric and quercetin in Tagetes erecta leaves. Using Carbapol 940 polymer, formulations (F1-F6) combining the extracts were developed and evaluated, with HPLC confirming the presence of Quercetin and Curcumin in the gel. Stability tests yielded satisfactory results after evaluation. Antimicrobial tests demonstrated higher efficacy against S. aureus compared to E.coli and Candida albicans.

Keywords: Turmeric, TLC, PHTLC, Curcumin, Antimicrobial activity.