Abstract

NEURODEGENERATIVE DISEASE: ALZHEIMER’S DISEASE

Vishal Thakur*, Mansi Sharma, Vishal Sharma, Dr. Akriti Singh, Suhaib Farooq

.

Abstract

Alzheimer's disorder(AD) is a neurological infection that impacts the old. Promotion annihilates synapses and causes cognitive decline and issues in thinking and conduct. The neuropathological sign of AD incorporates an amyloid plaque, neurofibrillary tangles, neuronal misfortune, and synaptic misfortune also.Progressive brain deterioration, as well as reduced activities of daily living and behavioral disorders,portray this condition. Dementia is the clinical state of Alzheimer's sickness (AD), which often begins with an unobtrusive and ineffectively saw the cognitive decline and continuously deteriorates with the result of deadening. Alzheimer's sickness is the main source of dementia. Dementia is caused due to a variety of neurodegenerative and cerebrovascular diseases, especiallyamong the elderly, proteotoxic stress, together with abnormalities in the ubiquitin-proteasome and autophagosomal/lysosomal systems. This disease (AD) is a synaptic dysfunction condition characterized by failures of molecular, cellular, and macro-scale cortical circuitry systems, with a preference for a cognitively eloquent brain. Changes in the APP, PSEN1, and PSEN2 qualities are connected with this condition. Diet and nourishment likewise play a huge impact in the turn of events and avoidance of Alzheimer's illness. The biomarker used to recognize dementia ought to have the option to recognize various reasons for dementia and identify it earlyon induced pluripotent stem cells have also been shown to be a successful treatment for curing this condition. The goal of this review is to shed insight on the path that leads to this disease and how stem cells can be used to treat it.

Keywords: Alzheimer‘s disease; Amyloid precursor protein; Neurofibrillary tangles; Oxidative stress; Genetics.