Abstract

SYNTHETIC STRATEGIES DUE TO NEW 1,2,4-TRIAZOLES GETTING (LITERATURE REVIEW)

*Prytula R. L., Shmatenko O. P., Bushuyeva ?. V. and Parchenko V. V.

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Abstract

1,2,4-Triazole is one of the most common "frameworks" in the synthesis of new biologically active molecules. Derivatives of the 1,2,4-triazole exhibit various types of biological activity and can fully satisfy the needs of the pharmaceutical industry for the creation of new drugs. This heterocyclic structure is the main component of various drugs available in clinical therapy: ribavirin (direct-acting antivirals), letrozole (aromatase inhibitors), itraconazole, fluconazole (fungicides), alprazolam (sedative agent). A wide range of biological and therapeutic properties of the 1,2,4 triazoles will encourage the scientific community to develop new accessible synthetic methods for their preparation for decades. Amidines, imidates, amidrazones, aryldiazoniums, and hydrazones are among the most relevant triazole precursors. The simplicity of construction and the strength of this heterocycle, as well as the possibility of highly selective introduction of "valuable" substituents into the composition of 1,2,4-triazole at the last stages, create a number of advantages over other organic substances. Thus, the generalization of literary sources in recent years regarding the synthesis methods of a number of new 1,2,4-triazole derivatives indicates the prospect of finding new biologically active molecules that can be the basis for the creation of original medicines.

Keywords: 1,2,4-triazoles, synthesis, transformation, chemical modification, biological activity.