Abstract

FORMULATION AND EVALUATION OF CONTROLLED RELEASE GASTRORETENTIVE FLOATING TABLET OF CHLORDIAZEPOXIDE

Nidhi Namdev*, Bhagwan Yadav and Dr. Sujit Pillai

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Abstract

Gastro-retentive drug delivery system (GRDDS) may be used to increase gastric retention time coupled with drug release for extended period of time to reduce more dosing frequency which may leads to plasma peak fluctuation. Chlordiazepoxide is a longacting benzodiazepine having anxiolytic, sedative & hypnotic activity. But, its multiple dose therapy leads to accumulation of parent compound and active metabolites causing various side effects. Chlordiazepoxide as GRDDS will reduce drug accumulation and side effects by maintaining plasma blood level. Formulations were prepared by direct compression method using HPMC and Ethyl cellulose as rate controlling polymers and were evaluated for thickness, diameter, weight variation, hardness, and friability along-with buoyancy studies and in vitro drug release study. The precompression & postcompression parameters were found within the acceptable limits. In vitro dissolution studies of all the formulations showed controlled release of drug over a period of 12hrs. Among all the twelve formulations, F12 was selected as a best formulation which had the better retardant effect (67.1% in 12 hours) & floating lag time of 70 sec. A floating drug delivery system using a suitable composition of HPMC K15M and ethyl cellulose could give the desired dissolution profile for formulating the controlled release tablets of Chlordiazepoxide.

Keywords: Chlordiazepoxide, Benzodiazepine, Anxiolytic, Gastro-retentive, HPMC.