Abstract

TITRIMETRIC AND UV SPECTROPHOTOMETRIC EVALUATION OF COMMERCIALLY AVAILABLE METFORMIN TABLETS

Radhika G.*, Aiswarya G., Ajith Babu T. K. and Krishnaja M. P.

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Abstract

The aim of this study was to quantify six brands of Metformin hydrochloride tablets. Quantification of different brands of Metformin hydrochloride tablets marketed in India using non-aqueous titrimetry and UV spectroscopic method are done to ensure whether both the methods give similar results for all brands as per labelled claim. UV spectroscopy is a method of analysis is based on measuring the absorption of a monochromatic light by colorless compounds in the near ultraviolet path of a spectrum (200-400nm). Distilled water is used as solvent. The λ max was found to be 232 nm. Solvent of choice in non- aqueous titrimetry is glacial acetic acid.

Keywords: Metformin, UV Spectrophotometry, Non aqueous titration.