Abstract

UV SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF VALSARTAN IN BULK AND TABLET FORMULATION

Kajal S. Jadhav*

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Abstract

A simple, accurate, specific and precise UV Spectrophotometric method has been developed for estimation of valsartan in pure and pharmaceutical formulation. The λmax of valsartan in 0.1N NaOH and water was found to be 250 nm. 0.1N NaOH and water is used as diluent in equal proportion. The drug exhibited the linearity in the concentration range of 5-25μg/ml with correlation coefficient of 0.999. The % recovery of the drug for the proposed was found to be 99.25 %. The limit of detection and limit of quantification was found to be 0.91% and 2.77% respectively. No interference was observed in the presence of common pharmaceutical excipient. The method was validated as per ICH guidelines. The developed method was successfully employed for the estimation of valsartan in pharmaceutical dosage form.

Keywords: Valsartan, UV Spectroscopy, Method development, Validation, Estimation.