Abstract

THE USE OF GLYCOCONJUGATES IN ANALYSIS OF PROTECTION AGAINST PATHOGENS: GENERAL RULES

Vladimir M. Lakhtin*, Mikhail V. Lakhtin and Aleshkin Vladimir A.

.

Abstract

The overview is devoted to our own data on the use of water-soluble glycoconjugates based on a linear polyacrylamide chain in relation to recombinant therapeutic human protein hormones and probiotic recognition proteins, such as enzymes and lectins. The results obtained characterize the basic principles of multilevel relationships between proteins and glycoconjugates, including the assembly of complexes and nanoparticles on a solid phase that mimics the cell surface. The prospects of applying these principles in the study of therapeutic proteins and other protein factors and cofactors, enzymes of all classes (including carbohydrate metabolism enzymes) of microorganisms and viruses are emphasized. The presented data will help in further development of protective network communication systems of organism. The data can serve the basis in search and construction of new effective combinations of drugs against infections and pathogens. These data will support the variety of applications in medical biotechnology.

Keywords: glycoconjugates; glycoproteins; carbohydrate-binding; CBM; enzyme carbohydrate sensitivity; protein factors; lectinbiotics; enzymebiotics; assemblies; recognition, communications; viruses; pathogens; probiotics.