Abstract

PHARMACEUTICAL STANDARDIZATION OF RASANJANA: A COMPREHENSIVE STUDY ON DARUHARIDRA-BASED RASAKRIYA PREPARATION

B. S. Kasturirangan*, Angadi Ravindra, B. N. Ashok Kumar, R. R. Geethesh4 and V. S. Sushmitha

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Abstract

Ayurvedic pharmaceutics plays a pivotal role in the systematic preparation of medicines adhering to Ayurvedic principles. This study focuses on Rasanjana, a unique rasakriya prepared from Daruharidra (Berberis aristata), renowned for its broad-spectrum utility in treating various ailments. Aims & Objectives: The primary aim of this study is to standardize the manufacturing procedure of Rasanjana, with a focus on the critical aspects of preparation. Materials & Methods: The pharmaceutical procedure involved the preparation of Daruharidra Kwatha, mixing Aja Ksheera to kwatha, and ultimately preparing Rasanjana. The study was preceded by multiple pilot studies, and the observations and critical factors were incorporated into the standard pharmaceutical procedure followed in this study. Results: Rasanjana, derived from 1.5kg Daruharidra, underwent an 8.5-hour process, yielding 520g. The preparation involved a Kwatha reduction to 3 litres, addition of 3 litres Aja Ksheera, resulting in brownish-yellow, bitter-tasting granules with a pleasant smell and unctuous touch. Discussion: The discussion delves into the challenges encountered during the pilot studies. The study emphasizes the importance of vessel selection, temperature control, and purification steps in ensuring the success of the preparation process. Conclusion: The research concludes with a comprehensive understanding of the factors influencing the quality and potency of Rasanjana. The choice of Daruharidra, the precise extraction techniques, and the interaction with Aja Ksheera contribute to the final product's efficacy. The study highlights the significance of attention to detail, ensuring the integrity of the pharmaceutical preparation.

Keywords: Aja-ksheera, vessel selection, temperature control, extraction techniques, granules.