Abstract

NANOPARTICLES USED AS A NOVEL DRUG DELIVERY SYSTEM

Krishna N. Shirsat* and Dr. K. Balireddy

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Abstract

A significant amount of research has been conducted in the last few years based on novel drug delivery systems, which use particulate vesicle systems as such drug carriers for both small and large molecules. Drug carriers in vesicle drug delivery systems include liposomes, nanoparticles, microspheres, niosomes, pronisomes, ethosomes and proliposomes. Nanoparticles are important to commerce, eight different types of particles will be examined orderly to evaluate the effects of size, shape, and composition on skin toxicity, absorption, and distribution. To create nanoparticles, a variety of polymers have been employed. Drugs' therapeutic effects have been enhanced and their negative effects have been reduced thanks to nanoparticles. A wide range of substances, including proteins, polysaccharides, and synthetic polymers, can be used to create nanoparticles. The three most common ways to create nanoparticles are dispersing preformed polymers; polymerizing monomers; and ionic gelation or coacervation of hydrophilic polymers. Evaluation of Nanoparticles is based on drug entrapment efficiency, particle shape, partical size and zeta potential. The impact of nanoparticles' interactions with the body depends on their size, chemical composition, surface structure, solubility, shape. Nanoparticles are applied in tumor targeting using nanoparticulate delivery system, gene therapy, cell repair and antimicrobial activity. Types of nanoparticals are liposomes magnetic dentrimars, nanogels, micells etc. there are huge future prospects of nanoparticals in medicinal approaches.

Keywords: Nanoparticles, polymerization, dispersion, liposomes, coacervation, nanomedicines.