Abstract

SOLID LIPID NANOPARTICLES (SLN): PREPARATION, CHARACTERIZATION AND APPLICATIONS

Dr. K. Sundaramoorthy and S. Jeevanraman*

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Abstract

Muller and Gasco around 1990s were firstly developed and nominated solid lipid nanoparticles (SLN) for the sake of avoiding organic solvents involved in preparation of polymeric nanoparticles. It is an alternative carrier system to traditional colloidal carriers, such as emulsions, liposomes and polymeric micro and nanoparticles. SLN increases the bioavailability of poorly soluble drugs and it facilitates the drug absorbtion through lymphatic system, so it helps to prevent the hepatic first pass metabolism of drugs. This paper review the present state of production techiniques for solid lipid nanoparticles, advantages, disadvantages, characterization and application of solid lipid nanoparticles.

Keywords: Novel carrier system, Nanoparticles Solid lipid nanoparticles, Bioavailability, Colloidal carrier.