Abstract

FORMULATION AND EVALUATION OF ANTI-PEPTIC ULCER CAPSULES OF CURCUMA LONGA HERBAL PRODUCT

Prof. Dr. Mahmoud Mahyoob Alburyhi* and Prof. Dr. Amina El-Shaibany

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Abstract

Curcuma longa has been used in traditional remedy for a wide range of ailments, including wound healing, urinary and gastrointestinal tract infections, and liver ailments and variety of symptoms such as inflammation, gastritis and gastric ulcer. When Curcuma longa extract was administered per oral to pylori-ligated rat stomachs, it reduced gastric acid secretion and protected against the formation of gastric mucosal lesions. Curcuma longa extract inhibits gastric ulcers by blocking the H2 histamine receptor. Curcuma longa is commonly used in traditional medicine for a wide range of ailments including gastritis and gastric ulcer. Anti-peptic ulcer of ethanolic extract of Curcuma longa was prepared and evaluated at the dose of 100mg/kg and showed a significant activity. Curcuma longa was formulate as capsules and evaluate for organoleptic properties of ethanolic extract of Curcuma longa. The results show that the formulation of extract capsules of Curcuma longa was sparingly soluble, particle size was very fine, tapped density was m /V1250 g /ml, flowability of extract powder moisture content was 4%. Dissolution and stability under various storage condition were also performed.

Keywords: Curcuma longa, Extract, Capsules, Anti-peptic ulcer, Herbal Medicines.