Abstract

DESIGN AND DEVOLOPMENT OF DILTIAZEM HYDROCHLORIDE SUSTAINED RELEASE DRUG DELIVERY SYSTEM

Thoutu Shiva Prasad* and Adukondalu Devandla

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Abstract

The present study was to design and development of sustained and controlled release drug delivery system with using drug Diltiazem Hydrochloride. Prepare the matrix tablets with using of different polymers with different grades. The polymers used hydrophilic HPMC K100, HPMC K4M. The hydrophobic polymers used Eudragit L100. The natural polymer Xanthan gum also used prepare formulations. First to develop the new formulation with drug and polymer. The tablets were prepared with using single polymer with different grade and using combination of polymers with different proportions. The matrix tablets were prepared by using direct compression method. Then those tablets subjected to pre-compression and post compression evaluation studies and in-vitro drug release studies. And also compare with marketed product of Diltiazem with prepared formulation and observe the evaluation studies. The above study was clearly indicated Diltiazem Hydrochloride formulated as sustained release tablet with using different polymers tablets shows achieve slow release of drug over an extended period of time after administration of dose. Drug releases at predetermined rate, for locally or systemically, for a specified period of time.

Keywords: Sustained release, Matrix tablets, Controlled release, Diltiazem Hydrochloride, Polymers, in-vitro studies.