Abstract

EVALUATION OF ANTIDERMATOPHYTIC ACTIVITY OF PEDALIUM MUREX L.

Dr.P.Abirami* and Dr.A. Rajendran

Abstract

Dermatophyte infections are very common in India where hot and humid climate along with poor hygienic conditions play an important role in the growth of these fungi. Trichophyton and Microsporum species forms the commonest etiological agent of dermatophytosis. In the present investigation, different solvent extracts of Pedalium murex L. were screened against two dermatophytes viz., Trichophyton rubrum and Microsporum gypseum. The prominent zone of inhibitions was observed in methanol and petroleum ether extract of Pedalium murex against in Microsporum gypseum at 200 μg/ml concentration. The distilled water and methanol extracts of Pedalium murex showed significant activity against Trichophyton rubrum. The standard drugs griseofulvin, fluconazole and ketoconazole were used as the positive control and zones of inhibition were from 10 to 20 mm.

Keywords: Dermatophytes, Pedalium murex L., antidermatophytic activity, methanol extracts.