Abstract

EVALUATION OF IN-VIVO ANALGESIC AND ANTIINFLAMMATORY ACTIVITIES OF ETHANOLIC LEAF EXTRACT OF CORDIA MYXA

Tekimudi Lovakumari*, K. Ravi Shankar, S. Amala and V. Bhaargavi

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Abstract

The presented research deals with the evaluation of analgesic and antiinflammatory activities of the ethanolic extract of Cordia myxa leaves on albino Wister rats. Analgesic activity was observed in albino Wister rats of both sexes using paradigms such as the tail flick method, the eddy hot plate method. While anti-inflammatory activity was observed using the carrageenan-induced paw edema method. In the tail flick method and eddy's hot plate method, rats were treated with the extract at doses (100 mg/kg and 200 mg/kg) Po was observed at 0, 15, 30, 60, 120 minutes. Rats treated with the extract were compared with standard tramadol (5 mg/kg). In the tail flick method, Cordia myxa extract at a dose of 200 mg/kg significantly increases the latency of the nociceptive reaction of the tail withdrawal from the heat source. In the eddy's hot plate method, the extract at a dose of 200 mg/kg significantly increases the latency of jumping and licking responses. In the carrageenan-induced paw edema method, rats were treated with the extract at doses (100 mg/kg and 200 mg/kg) Po and observed at 0, 1, 2, 3, 4 hours and compared with standard Diclofenac sodium (10 mg/kg). Leaf extract at a dose of 200 mg/kg showed maximum percent inhibition of paw edema in rats at 4 h.

Keywords: Analgesic activity, Anti-inflammatory activity, Carrageenan, Eddy's hot plate method.