Abstract

A REVIEW ON NON AQUEOUS NANO EMULSION

Khamkar Arun A.*, Shaikh Nikhat, Pawbake Akash B., Avhad Pratik A. and Gavhane Chandrabhan B.

.

Abstract

In general, emulsions are of the water-in-oil or oil-in-water type, but emulsions may contain a polar liquid as one of the phases. Nonaqueous nanoemulsions are useful in many situations where the presence of water is not desired and in the formulation of active ingredients that undergo hydrolysis or oxidation in the presence of water. Anhydrous nanoemulsion is the subject of a stable non-aqueous nanoemulsion (NANE) design using cosmetically approved ingredients as a vehicle for water-sensitive active ingredients. The non-aqueous nanoemulsion is the subject of increasing dermal penetration and permeation and studying drug solubility and dermal bioavailability. For better compliance, non-aqueous nano emulsions will be incorporated into cosmetics or personal care products. A non-aqueous system with glycerin and olive oil stabilized with glycerol monostearate with co-surfactant was obtained. It was observed that the emulsification behavior is completely unpredictable and the conventional theory of emulsification and HLB system cannot be applied here. By implementing a pseudoternary phase curve, an optimized non-aqueous nanoemulsion is obtained. The non-aqueous nanoemulsion region is determined and further characterized for pH, rheology, globule size analysis, zeta potential and stability.

Keywords: Non-aqueous nano emulsion, HLB, Pseudo-ternary phase curve, Zeta Potential.