Abstract

ADVANCEMENT IN BUCCAL DRUG DELIVERY FOR CONVENIENT ORAL INSULIN ADMINISTRATION

Dr. Manasa Swapna K. R.*, Syeda Madiha Firdous, Sayema Maryam, Saniya Zainab, Mohd. Zahed Ali and Syed Anas

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Abstract

The buccal mucosa drug delivery system refers to the administration of the drug through the buccal cavity as a site of drug absorption. Diabetes mellitus is one of the most lethal, non-communicable diseases. Insulin is normally used to medicate diabetes. Due to bioavailability issues, the most regular route of administration is through injection, which may pose compliance problems to treatment. The insulin gets absorbed directly into the bloodstream through the buccal mucosa, which is the inner lining of the cheek. Oral insulin spray is a novel drug delivery system that offers an alternative to the subcutaneous route of administration. The goal of this inventive approach is to improve patient compliance and convenience by abolishing the need for painful injections. Results showed that the oral insulin absorption and elimination was much faster when compared to subcutaneous injections and outperformed subcutaneous injections in terms of glucose and C-peptide lowering capacity as well as rise in the insulin levels.

Keywords: Buccal drug delivery system, oral insulin spray, novel drug delivery system, bioavailability issues.