Abstract

REVIEW OF TRANSDERMAL DRUG DELIVERY SYSTEM

Nikita Shinde*, Shubhangi Manikpuriya and Dr. Gajanan Sanap

.

Abstract

The oral route is the most common route of drug delivery, but the administration of drugs through the oral routeshows a few disadvantages, like first-passmetabolism, drug degradation in the gastrointestinal tract due to enzymes and pH of the stomach, GI irritation, low bioavailability, etc. To overcome this problems, the Transdermal Drug Delivery System (TDDS) was developed. Transdermal Drug Delivery Systems, also known as “Patches” are the painless way of systemically administering therapeutically active medication by placing a drug formulation on intact and healthy skin. Skin is an effective medium through which absorption of the drug takes place and entersin the blood stream overthe period of time. Different types of transdermal drug delivery systemsare developed, which demonstrate different release kinetics. This review article provides a detailed study of TDDS advantages, disadvantages, drug permeation pathways, types of transdermal drug delivery systems and their components, factors affecting the formulation of TDDS, and their evaluation parameters. The review also contains future prospects for transdermal drug delivery systems.

Keywords: Drug Penetration, Matrix, Reservoir, Polymer, Pressure Sensitive Adhesive, Pro-Liposomes.