Abstract

CHALCONES IN MEDICINAL CHEMISTRY: AN IN-DEPTH ANALYSIS OF STRUCTURE-ACTIVITY RELATIONSHIPS AND PHARMACOLOGICAL SIGNIFICANCE

Muizz Kachhi*, Yash Parsewar, Harshita Sachdev, Sagri Mane, Shraddha Garud, Hrithik Jain, Shivraj Mane Deshmukh and Nikhil Fegade

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Abstract

Background: Chalcones are among the leading categories of flavonoids across the entire kingdom of plant, The term chalcone is originated from the Greek name chalcos which means bronze. Chalcones were initially manufactured in the research lab in late 1800s Naturally existing chalcones were not separated till the year 1910. Chalcones possess a broad spectrum of biological activities including antioxidative, antibacterial, antihelmintic, amoebicidal, antiulcer, antiviral, insecticidal, antiprotozoal, anticancer, cytotoxic and immunosuppressive. Changes in their structure have offered a high degree of diversity that has proven useful for the development of new medicinal agents having improved potency and lesser toxicity and good pharmacological actions. Objectives:  To Study in detail about Chalcones  To Evaluate the Presence of Chalcones as a Potential API  To Know about the Possible Applications and the Effects of Chalcones.  To Draw Conclusions About the Anti-Inflammatory Activities of Chalcones.  To Analyze the Possible Advantages and Risks associated with the Use of Chalcones as an API. KeyFindings: Chalcones and Chalcone Derivatives, Pharmacological Activities of Chalcones, Anti-Inflammatory Activities of Chalcones, Sources and Synthesis of Chalcones. Conclusion: The purpose of this review is to summarize the most important pharmacological activities highlighting the cellular and molecular mechanisms of action of natural and synthetic chalcones, to better understand their therapeutic potential in the future while specifically focusing on their Anti-Inflammatory Activities.

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