Abstract

A COMPARATIVE PHARMACEUTICO-ANALYTICAL STUDY OF MUSTAKADI LEHA AND ITS MODIFICATION INTO GRANULES

Sivakumar B.* and M. S. Krishnamurthy

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Abstract

Mustakadi Leha, has been described in Bhaishajya Ratnavali in Kasa Chikitsa, especially in Kshayaja Kasa. Its consists of ingredients such as Musta, Pippali, Draksha and Brihati Phala. It is being consumed by mixing it with honey and ghee in Leha form. In current study, an attempt was made to convert Mustakadi Leha into an easily consumable, more absorbable form by modifying it into granules. Aim: To prepare Mustakadi Leha and its granules and to do comparative physico-chemical analysis of Mustakadi Leha and its granules. Method: The formulation was prepared in accordance with the text Bhaishajya Ratnavali. Avaleha Kalpana and its conversion into granules are the pharmaceutical processes included in this study. Organoleptic, physico-chemical analysis of Mustakadi Leha and its modified granules were carried based on API standard reference. Observation and Results: Modifying the preparation Mustakadi Leha into granules allows for experimentation with different ingredients and ratios, enabling the development of granules with targeted pharmaceutical study. Analytical evaluation of Mustakadi Leha and Mustakadi granules found satisfactory. Conclusion: The pharmaceutico- analytical study comparing Mustakadi Leha and its modified granules has revealed important differences in their preparation methods. Mustakadi Leha, prepared without heat treatment, likely preserves the natural properties and delicate constituents of its herbal ingredients. Conversely, Mustakadi granules, subjected to heating during formulation, may undergo compositional changes, resulting in the absence of acid-insoluble ash. Furthermore, the study revealed significant differences in sugar content between Mustakadi Leha and Mustakadi granules, making the Leha a more favorable option for individuals concerned about their sugar intake.

Keywords: Mustakadi Leha, Mustakadi granules, Bhaishajya Ratnavali, Kshayaja Kasa.