Abstract

NATURAL DRUG INTERVENTIONS FOR DUCHENNE MUSCULAR DYSTROPHY: A REVIEW

Dahmani Aboubaker El Ghifari, Shusheng Fan, Haowei Tong, Zhenzhou Jiang, Luyong Zhang*

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Abstract

Duchenne Muscular Dystrophy (DMD) is a severe issue in the field of neuromuscular disorders, needing novel treatment strategies. Natural substances with varied bioactive characteristics have emerged as interesting possibilities for combating DMD's relentless growth. This in-depth examination examines the present state of knowledge about the impact of natural substances on DMD management, including their methods of action, safety profiles, and therapeutic implications. Natural substances have a wide range of action mechanisms, including dystrophin restoration, anti-inflammatory and antioxidant activities, myogenic stimulation, and anti-fibrotic properties. Preclinical research has offered persuasive evidence of their therapeutic potential, and preliminary clinical trials have revealed insight on their safety and tolerability. However, issues such as a lack of clinical data, worries regarding compound standardization and safety, accessibility, and ethical problems remain. Enhancing clinical translation, developing combination medicines, using personalized medicine techniques, and verifying biomarkers and surrogate endpoints to optimize treatment strategies are some of the future prospects in this discipline. Innovative medication delivery technologies and mechanistic elucidation will help us comprehend natural chemical activities even more. Quality and safety will be ensured by regulatory developments and standardization efforts. Patient-centered research, which includes patient-reported outcomes and quality-of-life assessments, is still critical. This review highlights the promise of natural chemicals in improving the lives of people suffering from DMD.

Keywords: Neuro-muscle Therapeutics; Muscle Health; Neuromuscular Interventions; Myoprotective Agents; Bioactive Muscle Modulators.