Abstract

FORMULATION AND EVALUATION OF TRANSDEMAL DRUG DELIVERY SYSTEM: REVIEW

Bhavandra N. Choudhari*, Chahat S. Rahangdale and Bhawini S. Paulzagade, Sanket R. Bhiogade, Tina Lichade and Upadesh B. Lade

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Abstract

Transdermal drug delivery system is an alternative route for systemic drug delivery which minimizes the absorption and increase the bioavailability. With the help of solvent evaporation technique, polyethylene glycol 400 was used as a plasticizer, and different concentrations of penetration enhancers (tea tree oil, sweet basil oil, eucalyptus oil, dimethyl sulphoxide, and clove oil) were added to create a matrix-type transdermal system containing the medication clopidogrel bisulfate. Due to significant first pass metabolism (85%) and low oral bioavailability (50), frequent large dosages (75 mg) are needed to maintain the therapeutic level. The antiplatelet drug clopidogrel bisulfate, when taken orally, has a brief elimination halflife of 7-8 hours. It stops blood cells called platelets from clumping together and creating a potentially fatal blood clot. An oral thienopyridine-class antiplatelet medication called clopidogrel is used to suppress blood clots in various artery and vascular diseases as well as lower the risk of myocardial infarction and stroke. In this work, various matrix-type transdermal patches containing clopidogrel bisulfate were formulated to increase the bioavailability of the drug, as oral bioavailability of clopidogrel is poor due to high first-pass metabolism (only 15% metabolite in active form). These patches release and absorb the drug directly into the systemic circulation.

Keywords: Transdermal drug delivery, Transdermal patches, Clopidogrel bisulphate, polyethylene glycol, In- vitro drug diffusion studies.