Abstract

AN EXTENSIVE REVIEW ON SUBLINGUAL MINITABLET OF RESPIRIDONE AND EVALUATION BY MELT-GRANULATION METHOD

G. Hariharaputhraayyanar* and B. Manoj

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Abstract

Risperidone is an anti psychotic drug; mainly used to cure schizophrenia, bipolar disorder and autism spectrum disorder. Risperidone have short half life is 3 hours in extensive metabolizers and 20 hours in poor metabolizers. The oral bioavailability of risperidone is 70% due to highly bound to plasma protein and tissues and are extensively distributed. Risperidone is metabolized primarily into the liver and minimally through N-dealkylation. Required administration of frequent dosing of risperidone, maximum daily dose up to 1-3mg/day for the treatment of schizophrenia. The aim of this work to design and formulate and evaluation of sublingual tablets of risperidone as twice daily tablets, in order to speed up bioavailable time period and improve the patient compliance by Melt-granulation method. The plan of work is carried out the preformulation studies (Drug Characterization, Drug-Polymer Compatibility and Precompression Studies), formulation of sublingual tablet by direct compression method and evaluation of sublingual tablet (Uniformity of weight, Diameter and thickness, Hardness, Friability, Surface pH, Swelling Index, Drug content and In- vitro drug release) and determine the optimized formulation and the effect of polymers (PEG 4000, PEG 600), HPMC K100M and silicified MCC) and PVA used for easy dissolve in water due to its high melting point.

Keywords: Risperidone, sublingual, melt – granulation, PVA.