Abstract

A REVIEW ON HYDROTROPHIC SOLUBILIZATION METHOD

Pradija Sasidharan* and Aadhila N.

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Abstract

A significant problem in both formulation research and screening tests of novel chemical entities has been the solubilization of poorly watersoluble pharmaceuticals. Hydrotropic solubilization is one of the methods used to improve the aqueous solubility of weakly watersoluble medications. A substance that dissolves hydrophobic substances in aqueous solution is known as a hydrotrope. Aqueous solubility of poorly water soluble drugs and insoluble drugs can be increased by the phenomenon called hydrotropic solubilization. The emulsification issue, which is typically discovered in hydrotrope solutions are not present in normal surfactant solutions. This approach is the most efficient one, especially when used to industrial settings, due to the simplicity of recovering the dissolved solute and the potential for reusing hydrotrope solutions. Furthermore, this method is better than others due to its advantages, which include the solvent's pH-independent character, good selectivity, non-flammability, and inexpensive and convenient availability of hydrotropes. Hydrotropic agents include, sodium salicylate, sodium benzoate, urea, nicotinamide, sodium citrate and sodium acetate.

Keywords: Hydrotrophic solubilisation.