Abstract

CARBAMAZEPINE INDUCED HYPONATREMIA (ACUTE ENCEPHALOPATHY SHOCK)

Khuba Raniya*, Maryam and Maryam Sadiq

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Abstract

Carbamazepine-induced hyponatremia is a rare condition. The patients may or may not be symptomatic. Epilepsy is considered a social taboo. Hence, patients do not reveal history of being on antiepileptic agents. Carbamazepine is a known antiepileptic and psychotropic agent. It is commonly used for the treatment of seizures and psychiatric disorders. We present a case of 70 year old female patient was admitted in the MICU department with the history carbamazepine induced hyponatremia. It raises antidiuretic hormone (ADH) levels. This leads to increased sensitivity of renal tubules to ADH levels. Final diagnosis was carbamazepine induced hyponatremia with Acute Encephalopathy, shock on examination Echo (outside)-LVH, Normal LV function, Mild AR, MR, No PE/Clot, (outside)-sinus rhythm, Qt interval increased, ECG-Sinus tachycardia. She recovers significantly Hence, it is essential to monitor sodium levels in patients on carbamazepine therapy and also on drugs with similar mechanism of action.

Keywords: Anti diuretic hormone, Antiepiletic agent, Seizures, Endothelial dysfunction.