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Abstract

DESIGNING AND DEVELOPMENT OF IBRUPROFEN FLOATING TABLET

Fathima Fabina*, Dr. Ibrahim Afsal, Syam Prasad P. S., Fathima Hanan and Fathima P. M.

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Abstract

Study of Ibuprofen Floating tablets were to develop optimized gastric floating drug delivery system(GFDDS) by using polymers like HPMC K4M and Carbopol 940 to increase the bioavailability and therapeutic efficacy of ibuprofen. Floating drug delivery system have a bulk density lower than gastric fluids, thus remain buoyant in the stomach causing an increase in gastric residence time. The compatibility evaluations were performed by DSC analysis. Studies imply that polymers are compatible with each other. There was no interaction found between polymer and drug. The research was undertaken with the aim to formulate and characterize the sustained release floating tablets of Ibuprofen using HPMCK4M and Carbopol 940 as polymers. KEYWORDS: Ibuprofen, buoyancy lag time, HPMCK4M, Carbopol 940.

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