Abstract

FORMULATION AND EVALUTION OF ANTI MICROBIAL ACITIVITY OF TRANSDERMAL PATHES OF ETHANOLIC EXTRACT OF PONGAMIA PINNATA SEED

*M. Sakthivel, M. Mohammad Halith, A. Swetha, S. Thangamaniarasan, S. Velmathi and R. Vengatesh

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Abstract

The anti microbial acivity of ethanolic extract of dries seed of pongamia pinnata(karanja), is a popular growing tree in India, Africa, china. The plant are used as therapeutic agent such as anti inflammatory, anti cancer, anti diarrial, anti arthritis etc, The pongamia pinnata ethanolic extract was prepared maceration process the preliminary phytochemical screening was carried out by standard protocols. The antimicrobial efficacy of seeds of pongamia pinnata was carried by Kirby Bauer Agar Well Diffusion method at concentration of 100ug against selective Gram positive pathogens such as Staphylococus aureus, Bacillus subtilis, Enterococcus faecalis. Gram negative Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa. The results in the study indicate that the anti microbial activity depends upon their type of bacteria used for the study. This study evaluate the anti microbial activity of pongamia pinnata seed extract. The crude extract of the plant showed significant activity against tested organisms. This study also showed that the plant could be a potential source for new anti microbial agent.

Keywords: Anti microbial activity, Transdermal patch, Pongamia pinnata. Screening of anti microbial activity.