Abstract

REVIEW ON BUCCAL PATCHES CONTAINING PERINDOPRIL AND HYDROCHLOROTHIAZIDE

Manisha P.*

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Abstract

The objective of this study was to formulate and evaluate buccal patches containing hydrochlorothiazide (HCZ) and perindopril for sustained release. Films were fabricated by solvent casting using combinations of mucoadhesive polymers such as hydroxypropyl methyl cellulose (HPMC), hydroxypropyl cellulose (HPC), polyvinyl alcohol (PVA), polyvinyl pyrolidone (PVP) and ethyl cellulose (EC) as a backing layer. The patches were evaluated for physicochemical characteristics such as weight, thickness, surface pH, folding endurance, bioadhesive strength, swelling index, drug content, tensile strength, elongation at break and mucoadhesive time and ex-vivo permeation studies. The FT-IR spectral studies showed no interaction between drug and polymer. Physicochemical characteristics of all the formulations were satisfactory. The stability studies did not show any significant difference in external appearance, drug content, swelling index and ex-vivo drug permeation after a storage period of 2 months.

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