Abstract

RECENT ADVANCES IN THE SYNTHESIS AND APPLICATIONS OF PHARMACEUTICAL CO-CRYSTALS: A COMPREHENSIVE REVIEW

Romit Bhattacharjee*, Neha Paramanik, Amit Biswas, Himadri Sekhar Santra and Bishal Sarkar*

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Abstract

Pharmaceutical cocrystals have become a cutting-edge field of study, providing creative ways to improve medication qualities and get around formulation problems. The use of pharmaceutical cocrystals to modify the physicochemical properties has drawn attention in recent years due to the prevalence of poorly soluble APIs that exhibit poor and inconsistent bioavailability. In order to successfully develop the formulation with the desired pharmacokinetic profile, cocrystallization approach was established for adjusting the solubility, permeability, and processability of APIs by introducing another compatible molecule or molecules into the crystal structure without affecting its therapeutic efficacy. Co-crystals are multi-component systems in which a coformer and an active medicinal ingredient are bonded together in the crystal lattice by non-covalent interactions and are present in a stoichiometric ratio. The cocrystals exhibited improved solubility, dissolution rate and bioavailability indicating of potential of co-crystallization as a strategy to improve the therapeutics efficacy of the API.

Keywords: Co-crystals, Physiochemical properties, Coformer.