Abstract

FORMULATION AND EVALUATION OF ANTITUMOR ACTIVITY OF ARTEMISIA ARBORESCENCE EXTRACT CAPSULES AS DIETARY SUPPLEMENTS HERBAL PRODUCT AGAINST BREAST CANCER

Prof. Dr. Mahmoud Mahyoob Alburyhi* and Prof. Dr. Amina El-Shaibany

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Abstract

Artemisia arborescence plant widely distributed in Yemen, traditionally used to treat dermatitis, allergic reactions, itchiness lymphatic drainage, venous congestions Asthma, hay fever, asthmatic bronchitis. The essential oil of this plant was traditionally used as an insect repellant, as flavourings and for fragrances. Inhalation of the oil is used to dilate and stimulate the bronchi, blood vessels of the heart and to stimulate the kidneys. The oil is for inhalation only. Artemisia arborescence has been used traditionally as an anti-inflammatory remedy. The essential oil of Artemisia arborescence has been reported to have antibacterial and antifungal activities as well as antiviral activity against HSV-1 and HSV-2. Artemisia arborescence essential oil also exhibited antifungal activity against Cladosporium cucumerinum. The antitumor activity of Artemisia arborescence can be attributed to the presence of α-bisabolol and palmitic acid. Artemisia arborescence is commonly used in traditional medicine for a wide range of ailments including gastritis and gastric ulcer. Food poisoning commonly caused by salmonella typhimurium pathogenic gram-negative short rods. Artemisia arborescence is commonly used in traditional medicine for a wide range of ailments including gastritis, gastric ulcer and food poisoning. The antitumor activity of ethanol extract of Artemisia arborescence was evaluated at the dose of 100mg/kg and showed a significant activity for breast cancer. Artemisia arborescence was formulated as capsules and evaluate for organoleptic properties of ethanol extract of Artemisia arborescence. The results show that the extract was the best formulation F4 according to dissolution was 96.6% after 45 min, and stability under various storage condition were evaluated.

Keywords: Artemisia arborescence, Extract, Capsules, Herbal medicines, Breast cancer, Antitumor activity.