Abstract

THE ROLE OF BARETAB NUTRA DS IN DIRECT TABLET COMPRESSION METHOD

Rauf Pathan*, Monika Tomar and Amit Raj Sinha

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Abstract

BARETab Nutra DS is a novel Co-Processed excipients which is a combination of three Pharmacopeial excipients made by Co-Processing Technology. BARETab Nutra DS contains Dibasic Calcium Phosphate Anhydrous [DCPA] (Filler), Microcrystalline Cellulose (Binder) and Crosscarmellose Sodium (Disintegrant). BARETab Nutra DS offers excellent compressibility, good flowability with higher tablet hardness with less percentage friability and less disintegration time as compared to physical mixing and individual excipients. This is the main requirement for Direct Compression (DC) tablet formulation mainly in Nutraceutical tablet formulation. However, most individual excipients have insufficient physical characteristics, particularly in flowability and compressibility. Co-processed excipients are beginning to be used in the manufacturing of tablets and capsules to fulfill these requirements. All co-processed excipients have excellent flowability and higher compressibility and they have now carved out a niche for themselves in the Pharmaceutical and Nutraceutical sectors. In this study, We will make a Placebo Tablet of BARETab Nutra DS, Physical Blend, and Individual Excipient (MCC) by using direct compression method at the same thickness and same tablet weight and evaluate in-vitro parameters such as Weight Uniformity, Tablet Hardness, Friability and Disintegration time. BARETab Nutra DS is a high-functionality excipients to provides excellent tablet hardness, less friability and less disintegration time with superior flowability.

Keywords: Co-Processed Excipient, Higher Compressibility, Direct Compression (DC), Nutraceutical, Flowability, Compression Force, FTIR.