Abstract

NEUROPROTECTIVE EFFECTS OF POLYHERBAL FORMULATION ON ALUMINIUM CHLORIDE INDUCED ALZHEIMER’S DISEASE IN RATS

N. Tulasi Uma Rani*, S. K. Naina Sulthana and S. K. Meeravali

.

Abstract

Objective: The present study was designed to evaluate the Nootropic activities of Poly herbal formulation against aluminum Chloride induced Alzheimer’s disease (AD) in rats. Methodology: The current study was designed to investigate the neuroprotective effects of polyherbal formulation (PHF), 200mg, 300mg/kg, for 28days, Albinowistar rats of group 2 were treated with Aluminium chloride for 28 days. Behavioural studies are done by using Y-MAZE and ELEVATED PLUS MAZE. Other parameters such as RBCCholineesterase, Blood glucose, Hemoglobin, Body weights, food habits were observed. Results: This Study shows that the Aluminium chloride 4.2mg/kg does neuronal damage and memory impairment was observed. With behavioral changes, high RBC Cholinesterase levels, low hemoglobin levels, high blood glucose levels, gradually decrease in body weight and food habits. Treatment of PHF 300mg/kg shown effective compared with other groups. Conclusion: The present study revealed that poly herbal formulation of 300mg/kg significantly reduces RBC-Cholinesterase levels, Blood Glucose levels, Increased Hemoglobin levels, Body weight, Food habits are normal. And increased neuroprotection.

Keywords: alzheimer ’s disease, Nootropic activity, Neuroprotection, Aluminium chloride, Donepezil, RBC-Cholineesterase, Behavioural changes, Blood glucose, Hemoglobin.