Abstract

HUTCHINSON GILFORD PROGERIA SYNDROME - A REVIEW

P. Sailaja, Y. Prapurnachandra, M. Uma, N. Sai Varshitha, M. Manaswini, S. Tasleem* and L. Vinod

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Abstract

Hutchinson-Gilford Progeria Syndrome is a very rare disorder characterized by premature aging caused by a mutation in the LMNA gene. The child born with this disorder shows features of old age from the first year of birth and generally dies in the teenage. The clinical symptoms include alopecia, thin skin, stiffness of joints, etc. All of the children suffering from this disease appear identical. The pathophysiology of the disease is not very clearly understood. Various methods for diagnosis are being developed and clinical trials on some drugs that may be used in treatment are being carried out. The aim of this review is to understand the various aspects of the disease with special emphasis on pathophysiology, symptoms, recent trends in treatment, and future opportunities.

Keywords: The pathophysiology of the disease is not very clearly understood.