Abstract

A REVIEW ON NANOPARTICLES THE MAGIC BULLET CONCEPT FOR THE TREATMENT OF CHRONIC PULMONARY DISEASE

Dipak U. Adhav*, Javed A. Bagwan, Mayuri S. Avdhut, Disha D. Ade and Snehal S. Dhewale

.

Abstract

Chronic pulmonary diseases, encompassing conditions such as chronic obstructive pulmonary disease (COPD), pose significant challenges in their treatment due to the complex nature of the lungs and the need for targeted medication delivery. Nanoparticles face challenges for targeted and controlled drug release within the lungs. This review explores the potential of nanoparticle-based drug delivery systems as the "magic bullet" for treating chronic pulmonary diseases. In the context of lung diseases like chronic obstructive pulmonary disease (COPD) and Asthma, a magic bullet treatment would ideally be a medication that precisely targets the underlying cause or mechanism of the disease, providing significant relief or a cure without causing adverse effects or impacting healthy tissues. NPs have the potential to be effective drug carriers when combined with targeting ligands and possess many of the properties of a miracle cure. The term "miracle cure" originates aimed only at killing parasites in the body and ultimately has minimal negative effects on the human body. The drug's ability to harm multiple targets makes it a "magic shotgun" rather than a silver bullet. There is still a long way to go to achieve this miraculous goal. Nanoparticles can protect drugs from degradation, improve their solubility, and enable controlled release, ensuring efficient drug delivery to specific lung regions. Understanding the design, properties, and challenges associated with these innovative systems is crucial for advancing the development of effective therapies for chronic pulmonary diseases, offering hope for improved patient outcomes and enhanced quality of life.

Keywords: Nanoparticle-based drug delivery, Chronic pulmonary disease, Pulmonary drug delivery, Magic bullet concept.