Abstract

FORMULATION, OPTIMIZATION, AND IN VITRO RELEASE OF BOSWELLIA SERRATA (65% API) CAPSULE: A NOVEL HERBAL MEDICINE FOR OSTEOARTHRITIS

Sourav Kumar Sahoo* and Swapneswar Panda

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Abstract

Boswellia serrata (BS) is a well-known herbal medicine for osteoarthritis. It is one of the most potent herbal medicines. It has been used as a traditional medicine for the treatment of arthritic diseases. The present study was aimed to formulate, evaluate, and enhance the solubility profile of boswellia serrata (65% api) and make a capsule dosage form. It is prepared by solid dispersion and solvent evaporation using, tween 80 and tpgs as emulsifiers. The solubility profile of the capsule was evaluated by hardness test, friability study, disintegration time, and in vitro dissolution study. It was found that the optimized formulations, f11 capsule, api capsule, and control api capsule showed acceptable solubility and high permeability. So, it is concluded that using the TPGS as potent surfactant the capsule showing acceptable solubility, in-vitro drug release was significantly improved. The drug release was significantly improved, and the disintegration time was found to be 5 times greater. The results showed that the formulation f11, api capsule, and control api capsule showed acceptable solubility. So it concluded that the optimized formulation having enhance solibility and highly permeability.

Keywords: Boswellia serrata (BS), surfactant, emulsifier, tpgs, tween 80, solvent evaporation, osteoarthritis, in vitro dissolution, solubility, permeability, cumulative release, frankincense.