Abstract

BENZIMIDAZOLE-TRIAZOLE HYBRIDS WITH DIVERSE BIOLOGICAL ACTIVITIES: A SYSTEMATIC REVIEW

Nahana C. P.*, Shadiya C. K., Akash Marathakam and Vajid P. K.

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Abstract

Benzimidazole and triazole are important heterocyclic compounds and shown a wide range of pharmacological actions like antimicrobial, anti-inflammatory, antitubercular, anticancer and antiviral. On the other hand, molecular hybridization is a structural modification technique in the design of new ligands which consist of two or more pharmacologically active molecules in one structure. Benzimidazole and triazole can be fused using either functional group or bonds. Researchers hypothesised that these moieties might be joined to produce new or modified hybrid compound. This review summarized to know about the chemistry of benzimidazole-triazole hybrids along with theirpharmacological activities.

Keywords: benzimidazole; triazole; hybrid; anti-cancer; antidiabetic; anti-fungal.