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Abstract

CARDIAC MARKERS INTEGRITY IN WISTAR RATS MODEL FED WITH AQUEOUS EXTRACTS OF PHOENIX DACTYLIFERA, CYPERUS ESCULENTUS AND SOYBEAN WITH COD-LIVER OIL

Dr. Solomon M. Uvoh*, Dr. Kiridi Emily Gabriel E. and Dr. Blessing Leelee Dum-Awara

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Abstract

This study determine the nutritional and physiological role of cyperus esculentus, phoenix dactylifera, soybean aqueous extract, cod liver oil (standared drug) and the combination of both phoenix dactylifera, cyperus esculentus and soybean extracts on the integrity of cardiac markers using wistar rats model. The cardiac markers aimed at in this study includes troponin I, troponinT, CKMB, AST, and myoglobin using enzyme immunoassay, electrophoresis methods measured in pg/mls, U/L, ng/ml respectively. The study was design in such a way that group1 serve as the control while group2 to group4 served as the test groups with the administration of 1500mg/kg cyperus esculentus (gp2) and 700mg/kg phoenix dactylifera extracts. Group3 received 800mg/kg cyperus esculentus, 1600mg/kg phoenix dactylifera and 1200mg/kg soybean extract daily while group4 was administered 400mg/kg standared drug (codliver oil) daily. The results from this study indicate the cardiogenic protection and benefit of these nut fruits to maintain the integrity of cardiac markers and promotes physiological normalcy within the heart that serve as the power house of the cardiovascular system. However we observed an increase in troponin T(123pg/ml) in group2 with a significant difference and myoglobin (16.20ng/ml) in group4 though not statistically significant compared with other cardiac markers. A strong positive correlation between troponin I versus troponin T and CKMB was also observed. The deccrease in cardiac markers concentration/level are vivid manifestation of these nut fruits ability to promote cardiac health integrity and other cardiovascular parameters for smooth oxygen supply to satisfy all tissues demand in the body.

Keywords: Cardiac markers, Troponin, Myoglobin, Creatinine kinase, CKMB.


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