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Abstract

HIRSCHSPRUNG DISEASE, AN OVERVIEW WITH DIAGNOSIS AND CURRENT TREATMENT SCENARIO

Vartika Jain, Prity Raj Sinha, Asmita Roy, Pooja Biswas, Soujannita Majumder, Aman Kushwaha*

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Abstract

Hirschsprung disease, an common disease, as the enteric nervous system develops, its function is affected by the lack of ganglion cells in the submucosal and myenteric plexuses of the distal intestine. To diagnose Hirschsprung's disease, histological examination of surgical specimens or colonic biopsies found no ganglion cells. An additional technique that can aid in the diagnosis, particularly in challenging instances, is acetylcholinesterase (AChE) staining, which identifies the enhancementin the muscular mucosa and lamina propria of parasympathetic nerve fibers. Surgical intervention is typically required following a diagnosis of Hirschsprung's illness. A range of complications, from 4% to 16%, have been reported with various pullthrough surgery procedures for Hirschprung’s disease.

Keywords: Hirschsprung disease, ganglion cells, colonic biopsies, pull-through surgery.


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