Abstract

REVIEW ON FORMULATION AND EVALUATION OF NANOGEL

A. Priyadharshini*, M. Sujitha and Dr. K. Sundaramoorthy

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Abstract

The term „Nanogel‟ is defined as the nanosized particles formed by physically (or) chemically crosslinked polymer network that swells in a good solvent. Nanogels are crosslinked nanoscale particles made of flexible hydrophilic polymer ranging from 100-1000 nm. Nanogel are 3D network. Due to their relatively high drug encapsulation ability, consistency, effortless preparation, negligible toxicity, and stability in the presence of serum, including stimuli responsiveness, these studies integrate characteristics for topical drug delivery. Due to the entrapment of nanoparticles in the gel matrix, nano gel used as dermatological preparation has prolonged exposure times on the skin, thereby extending the duration of therapeutic efficacy. These are watersoluble and allow immediate drug loading in aqueous media. These are syntheses by various methods like precipitation polymerization, photolithographic technique, micro-molding method, membrane emulsification, reverse micellar methods, etc. Where properties of nanogel should be definite size, swelling, high loading capacity, and stability. Promethazine hydrochloride is a firstgeneration antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness. Promethazine, originally known as 3,277 R.P., is an Ndimethylaminopropyl derivative of Phenothiazine that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a few indications including allergic reactions, pain, sedation, nausea, and vomiting. The application of nano gel in various diseases like allergic conditions, autoimmune disease, local anesthesia, ocular drug delivery, and topical drug delivery. The drug delivery method using nano gel needs more indepth research to better understand how cells and molecules interact with them and how to overcome limitations.

Keywords: Nanogel, nano-scale particle, cross-linkage, 3-D network, gel matrix, topical drug delivery, polymerization, promethazine hydrochloride, allergic condition, anti-histamine, high loading capacity.