Abstract

A REVIEW ON SOLID DISPERSION TECHNIQUE FOR ENHANCING SOLUBILITY OF POORLY SOLUBLE DRUGS

Javed A. Bagwan*, Dipak U. Adhav, Disha D. Ade, Dipali D. Bhalerao and Mayuri S. Avdhut

.

Abstract

Solid dispersion, defined as the dispersion of one or more active pharmaceutical ingredients in a carrier in the solid state, is an efficient technique for improving the dissolution and bioavailability of poorly water-soluble drugs. Solid dispersion has attracted considerable interest as an efficient means of improving the dissolution rate and hence bioavailability of a range of hydrophobic drugs Oral route is mostly preferred for administrating drug to patients. But due to the poor solubility many drugs have limited used in oral administration. Enhancement of water solubility of poor water-soluble drugs is in main target in a pharmaceutical field. Solubility is one of the most important factors which affect dissolution rate and bioavailability. Solid dispersion is widely employed technique in pharmaceutical science to enhance solubility of poorly soluble drugs this review article delves into the various aspect of solid dispersion, highlighting its significance and application in drug formulation and development.

Keywords: Classification; Solid dispersion; Solubility; Dissolution; Bioavailability.