Abstract

NANOEMULGEL: AN EMERGING PLATFORM FOR TRANSDERMAL DRUG DELIVERY

Reethu Shree S.*, J. Adlin Jino Nesalin, E. Gopinath, Ganesh N. S. and Vineeth Chandy

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Abstract

The majority of newly developed drugs are lipophilic, which results in pharmacokinetic variations, low oral bioavailability, and uneven absorption. In order to prevent such disruptions, it has been demonstrated this innovative transdermal delivery method is superior to traditional oral route. Nanoemulgel, a newly developed transdermal delivery technology has demonstrated the good results for lipophilic medicines when compared to existing formulations. Nanoemulgel is a fusion of two different delivery systems, involves the physical state of drug containing nanoemulsion which is changed by adding it to the gel matrix. These nanoemulgels are essentially gelled oil-in-water nanoemulsions that have been mixed with a gelling agent to enhances stability and permits controlled and immediate release of medication. Additionally, nanoemulgel is receiving increased attention due to its ability to achieve a safe, targeted distribution, and non-gastrointestinal degradation or first-pass metabolism. In Nanoemulgel it is also possible to promote the drug's solubility in the vehicle and are a good option for analgesics and antifungal medications. In essence, high and low-energy methods are used to combine a hydrogel matrix with a nanoemulsion system to create nano-emulgel. Nanoemulgel provide compelling evidence for these nanocarriers stability in terms of their effectiveness and safety. The nanoemulgel with their non-greasy, gel-like properties and relatively high drug release rates, they can be effectively used for transdermal application.

Keywords: Nanoemulgel, Lipophilic drugs, Transdermal drug delivery, Gelling agent.