Abstract

OPTIMIZING ELUXADOLINE'S SOLUBILITY THROUGH THE SOLID DISPERSION SOLUBILIZATION PROCESS

Bindu Rathore, Mahendra Sharma*, Ramu Kaushal and Satendra Tiwari

.

Abstract

Aim of study was to enhance solubility of eluxadoline by solid dispersion method. In contrast to pure Eluxadoline, the in-vitro dissolution test showed a significant improvement in the dissolving effectiveness of solid dispersions; it was evident that solid dispersion (SD) technology has greatly accelerated medication dissolving speed. The Eluxadoline dispersion was made with PEG 4000 and HPMC, and it produced a significant percentage output and drug concentration across all solid dispersions. FT-IR and DSC investigations revealed no interaction between the drug, polymer, and solid dispersion formulation. Eluxadoline solid dispersion with hydrophilic polymeric transporters may increase systemic circulation by increasing water solubility and dissolving rate. When combined with a medicine such as PEG4000 and an HPMC ratio of 1:4:1, eluxadoline demonstrated high solubility and dissolving rate for solid dispersions created by solvent evaporation. Therefore, water-insoluble drugs like Eluxadoline can have their bioavailability increased by solid dispersion utilizing the solvent evaporation approach.

Keywords: Eluxadoline, Solid Dispersion, Solubilization, HPMC, Solvent Evaporation, Fusion Method.