Abstract

INDIAN HERBS IN THE TREATMENT OF LIVER INJURY: A MECHANISM-BASED REVIEW

Shashikala Sonwani* and Trilochan Satapathy

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Abstract

Object: The current study aims to investigate Indian herbs as potential effective liver injury treatments. Liver damage is an inflammatory condition that affects the liver and can be caused by a variety of factors, including changes in lifestyle in both men and women. Methods: The liver is an essential organ that is involved in the metabolism and removal of foreign substances from the body. Liver damage by various toxic chemicals (such as certain antibiotics, chemotherapy drugs, carbon tetrachloride (CCl4), thioacetamide (TAA), and microorganisms) as well as excessive alcohol use cause liver cell injury. The important health issue of liver malfunction or injury presents difficulties for the pharmaceutical Industry, drug regulatory organizations, and healthcare practitioners. The synthetic medications used to treat liver diseases in this situation also induce liver damage. As a result, herbal medications are used widely and have gained popularity. For a very long time, herbal remedies have been utilized to heal liver ailments. Results: In the present work, the plants used in this investigation were categorized using a table that included information about each plant's particular part of plants, pharmacological activity, extraction solvents, dosage, animal choice, and the results of hepatoprotective studies. Conclusion: This study compiled the various herbal plant have hepatoprotective properties which have been studied experimentally. Medicinal plants have hepatoprotective properties due to their ability to reduce oxidative stress and modify metabolic pathways that are connected to hepatotoxicity. This review may provide for further studies on pharmacological evaluation of hepatoprotective medicinal plants in systematic manner.

Keywords: Indian herbs, safety, active constituent, treatment, liver injury, hepatoprotective.