Abstract

ROLE OF NANOPARTICULATE DRUG DELIVERY IN THE TREATMENT OF PARKINSON'S DISEASE

*Dr. Putta Rajesh Kumar, Shivaleela U., Meena N., Poojitha P., Sowjanya P. and Dr. JVC Sharma

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Abstract

Parkinson’s disease is a most common neurological disorder (ND), it faces an absence of credible drug delivery,treatment and diagnosis. levodopa is the best drug of choice among the current conventional products designed as anti-parkinson drugs, but it’s poor brain transfer and low bioavailability are the most challenging problems for levodopa. To address these drawbacks, drug delivery levodopa. To address these drawbacks, drug delivery nanoparticles (NPs) acted as an outstanding tool for optimising the medicinal effectiveness of antiparkinson drugs. Nanoparticles enabled the drug to be administered via various routes to eliminate the demand to pass the blood-brain barrier (BBB). Also, the diagnosis of Parkinson’s disease(PD)in the early stage is another wing of efficient management of this disease. There are several barriers to the traditional diagnosis of disease. Nanotechnology could provide an insightful solution to this problem. The current study examines the recent innovations in the improvement of nanotechnology diagnosis and treatment platforms for Parkinson’s disease. A number of nanoparticles (carbon nanotubes, silver, gold, graphene, etc). Along with different approaches to biosensing and treatment are discussed here which have the potential to be used in Parkinson’s disease (PD).

Keywords: Nanoparticles, Blood-brain barrier, Parkinson’s disease.