Abstract

EFFECT OF TAMRA BHASMA IN HEPATOTOXICITY INDUCED BY MONOSODIUM GLUTAMATE – AN ANIMAL STUDY

Radhika Vadinge*, Mamata Narwekar, Sanjay Nandedkar and Swagat Patil

Abstract

Most of the disorders caused in present scenario are due to unconventional etiology such as indiscriminate use of pesticides fertilizers in the farming, food adulteration, food additives, preservatives, sweetener, indiscriminate use of various synthetic drugs etc. For this unconventional etiology, these substances are known to cause oxidative stress in human body.[2] Although Monosodium Glutamate has been used in food since many years, recent concerns have developed over the safety of consuming large amounts of this compound over a prolonged period of time as it can lead to many health related issues.[1,17] Many types of research on animals have led to the conclusion that Monosodium Glutamate may be the cause of adverse health effects affecting every organ in human body eg obesity, nephrotoxicity, hepatotoxicity.[3] The Monosodium effect on liver can be compared with the concept of Gara visha. Tamra bhasma is used in different conditions like skin, pleeha, netra rog. In Agadtantra there is reference in Charak Samhita that it having Gara vishaghna property as well as doing Rasayana karma on body. Oxidative stress is one of the cause that is responsible for Monosodium Glutamate toxic effect on liver. The current study was designed to find out Ayurvedic formulation to treat the hepatotoxicity with its in vivo study to screen its effectiveness in albino wistar rats. The pathological obtained results conspicuous observation have been discuss with scientific reasoning.

Keywords: Tamra bhasma, Monosodium Glutamate, Hepatotoxocity.