Abstract

A REVIEW OF THE SOLUBILITY ENHANCEMENT TECHNIQUE

Saloni Chouhan*, Shreya Nigam, Shraddha Jaiswal and Vaishali Chachriya

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Abstract

Solubility enhancement techniques are critical in pharmaceutical development to improve the dissolution rate and bioavailability of poorly water-soluble drugs. This review explores various techniques employed to increase drug solubility, leading to enhanced drug delivery and therapeutic effectiveness. The techniques covered include particle size reduction (milling, micronization), amorphous solid dispersions (ASDs), solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs), cyclodextrin complexation, nanoemulsions and microemulsions, salt formation, and pH adjustment. Each technique's principles, advantages, challenges, and applications are discussed to provide a comprehensive understanding of their potential benefits and limitations.

Keywords: Solubility, Solubility enhancement, Supercritical fluid, Nanoemulsion, PH.