Abstract

IN SILICO MOLECULAR DOCKING STUDIES OF CYCLOARTOMUNIN COMPOUND AGAINST CANCER PROTEINS

S. Shervinjose*

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Abstract

Cycloartomunin is a Pyranoflavonoids compound present in root and bark of Artocarpus family plants such Artocarpus hirsutus,Artocarpus altilis, Artocarpus communis and Artocarpus heterophyllus. Flavonoids are having antioxidant and anti-inflammatory effects that help control inflammation, kill cancer cells, and prevent heart disease. In this study, cycloartomunin was docked against pass analysis predicted activity proteins (HIFIA, NOS2, P65, TP53, AR, MMP9) and cancer protein such (CEA, C-Reactive protein, TNFalpha, BCL2, IL9, SOX2, ERBB2, APC, JUN, PTEN. PIK3CA, KRAS, EGFR, BRCA1, MITF, MYC). From the Insilico research completed, we can infer that Cycloartomunin show great efficacy in finding against cancer and can be used in cancer care. In Pharmacokinetic properties high gastrointestinal absorption and CYP2C9 inhibitor activity and Toxicity Prediction it is safety for consumption.

Keywords: Insilico study, Molecular docking, Artocarpus, Artocarpus hirsutus, Pass analysis, ProTox-II, Cancer protein, Pharmacology.