Abstract

EVALUATION OF CYTOTOXIC POTENTIAL OF MOMORDICA CHARANTIA

*Rohan Ingawale, Sandesh Chavan, Ashwini Sarak, Shweta Bhate, Gouri Shikhare, Aishwarya Sutar and Preeti Patil

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Abstract

Globally cancer is a disease which severely effects the human population. There is a constant demand for new therapies to treat and prevent this life-threatening disease. Nowdays focusing on the naturally occurring compounds for treating cancer due to the rich history of natural products playing a significant role in human ailment treatment, including cancer. Natural products have led to the discovery of many cancer chemotherapeutic agents like Taxol, vinblastine, and camptothecin, which have unique structures and mechanisms of action that are best discovered through isolation from natural sources. Momordica charantia, commonly known as bitter melon or bitter gourd, is a plant from the Cucurbitaceae family with the various phytochemicals such as Alkaloids, Triterpenoids, Saponins Flavonoids and Phenolic Compounds. These phytochemicals collectively play a significant role in the pharmacological activities of Momordica charantia, including its antidiabetic, antioxidant, anti-inflammatory, and immunomodulatory effects. Study revealed that the chemical constituent Charantine present in the fruit has the Cytotoxic effect againts the BSL Asaay. our Study suggested that Charantine might be a potential lead for anticancer drug discovery.

Keywords: Study revealed that the chemical constituent Charantine present in the fruit has the Cytotoxic effect againts the BSL Asaay.