Abstract

PREPARATION AND EVALUATION OF ANTIPARKINSONISM DRUG LOADED POLYMERIC NANOPARTICLES FOR BRAIN TARGETING

Priyanka Bhati and Utkarsh Tiwari*

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Abstract

We have prepared and characterized the primaxazoledihydrochloride nanosuspension and showed potential neuroprotective effects in both invitro and invivo. The administration of nanosuspension significantly rescued the neuronal perturbations compared to the nonformulated pure drug which lend a hand in the enhancement of primaxazoledihydrochloride nanosuspension to cross the BBB for treatment in Parkinson’s disease. The particle size was found to be 195 nm for formulation PPNP3. The entrapment efficiency was found to be 86.21% for formulation PPNP3. More than 85% drug release was observed in PPNP3. The zeta potential of PPNP3 was found to be 34.8mV. PPNP4 were rejected due to high content of polymer.

Keywords: Nanosuspension, Blood Brain Barrier, Parkinson’s disease, Neurons.