Abstract

CELL CYCLE MODULATORS REGULATING THE BASIC UNIT OF LIFE FOR DISEASE TREATMENT AND TISSUE REGENERATION

Prof. Sandip Pagare, Prof. Ashwini Pagare, Miss. Shrunjal Wankhede, Mr. Lokesh Mahale, Mr. Hemraj Ahire, Miss. Pratibha Kuwar

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Abstract

The intricate dance of cell division, known as the cell cycle, is fundamental to all living organisms. This meticulously orchestrated process ensures the precise duplication and inheritance of genetic material during cell proliferation. Disruptions in the cell cycle are hallmarks of various diseases, including cancer, and hinder tissue regeneration. Therefore, targeting cell cycle modulators presents a promising therapeutic strategy for disease treatment and tissue repair. This review article delves into the diverse array of cell cycle modulators, exploring their mechanisms of action and potential applications in various disease contexts. We discuss the therapeutic implications of targeting key regulators like cyclin-dependent kinases (CDKs), their cyclin partners, and checkpoint proteins. Additionally, we explore the potential of harnessing cell cycle modulators to promote tissue regeneration following injury or disease. By providing a comprehensive overview of cell cycle modulators and their therapeutic potential, this review aims to stimulate further research and development efforts towards novel therapeutic strategies for an array of diseases and tissue regeneration challenges.

Keywords: cell cycle; disease treatment; tissue regeneration; cell division; cyclindependent kinases (CDKs); cancer; cell cycle modulator.